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GLYCOPROTEINS, DESIALYLATED
Descriptors Found:
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DeCS
Descriptor
English
:
Asialoglycoproteins
Descriptor
Spanish
:
Asialoglicoproteínas
Descriptor
Portuguese
:
Assialoglicoproteínas
Synonyms
English
:
Desialylated Glycoproteins
Glycoproteins, Desialylated
Tree Number:
D12.776.395.140
Definition
English
:
Endogenous
glycoproteins
from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the
ASIALOGLYCOPROTEIN RECEPTOR
which is located on hepatocyte
plasma
membranes
. After internalization by adsorptive
ENDOCYTOSIS
they are delivered to
LYSOSOMES
for degradation. Therefore receptor-mediated clearance of
asialoglycoproteins
is an important aspect of the turnover of
plasma
glycoproteins
. They are elevated in serum of
patients
with HEPATIC CIRRHOSIS or
HEPATITIS.
See Related
English
:
Asialoglycoprotein Receptor
History Note
English
:
85
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
1219
Unique Identifier:
D001212
Occurrence in VHL
:
Similar:
DeCS